Preheat the oven to 350°F. Grease a 9x5-inch loaf pan and set aside.
In a large bowl, mix all the meatloaf ingredients together.
1½ pounds ground beef, ½ onion, 1 cup breadcrumbs, 1 tablespoon Worcestershire sauce, 1 teaspoon kosher salt, 1 teaspoon Italian seasoning, ½ teaspoon ground black pepper, ½ teaspoon garlic powder, 2 large eggs
In a separate smaller bowl, whisk together the glaze ingredients.
½ cup ketchup, 1 tablespoon brown sugar, 1 tablespoon red wine vinegar
Transfer the meatloaf mixture to a greased loaf pan, and spread the glaze on top.
Bake for 50-55 minutes.
Let the meatloaf rest for 10 minutes before slicing.