This crockpot Mississippi pot roast is a recipe I come back to time and time again. Seasoned with a quick ranch dressing and tangy pepperoncini, it’s juicy, tender, and just the right amount of zesty. I made it in my slow cooker for a hands-off approach, and I don’t think I’ll ever make it another way again! I love it on tacos, nachos, sliders, and more!

A Mississippi pot roast slow cooker full of meat and peppers.

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When I decided to make this Mississippi roast in a crockpot, I knew it was going to be a staple at my house. There’s no appliance I love more than my slow cooker, and this roast is so delicious and versatile. The butter, ranch, au jus, and pepperoncini make this pot roast so rich, juicy, and flavorful. I love the peppers, the sauce… everything!

What’s in This Mississippi Pot Roast Recipe?

  • Chuck Roast: I like a boneless top or bottom round chuck roast for this recipe, as it stays nice and tender. You can use a different cut, such as a rump roast, brisket, or even pork roast.
  • Flour: All-purpose flour helps create a crispy crust on the outside of the roast.
  • Oil: Helps the roast sear without burning. I like canola oil for its neutral flavor and high smoke point, but any neutral oil will work.
  • Butter: Unsalted butter keeps the roast moist as it cooks.
  • Pepperoncini: Add a tangy and mildly spicy flavor to the roast.
  • Mayonnaise: Forms the creamy base of the ranch dressing, which helps keep the roast moist.
  • Vinegar: Apple cider vinegar adds tangy flavor to the dressing.
  • Spices: Dried dill and ground sweet paprika enhance the flavor of the ranch.
Mississippi pot roast-inspired Mexican pulled pork in a white bowl.
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Tips for Success

  • There’s no need to add any water or broth to this recipe. It will make plenty of liquid as it cooks!
  • If your roast is not tender, it likely needs to be cooked for longer. This cut needs a low and slow cook to become meltingly tender.
  • For a complete one-pot meal, I like to add some vegetables like carrots, potatoes, sweet potatoes, or bell peppers, in the last 1-2 hours of cooking. Quarter the larger veggies (like potatoes) so they cook evenly.
  • If you prefer to make it in the oven, sear the roast and place it in a baking dish. Sprinkle with the seasonings, slice up butter and place over roast, and toss in some pepperoncini. Bake in a 300°F oven for about 2½ hours. Check for doneness, and continue to roast until the meat reaches the desired level of doneness.
  • Pot roast is ready to be shredded when it registers 195-200°F on an instant-read thermometer.

How to Store and Reheat

Store leftover crockpot Mississippi pot roast in an airtight container in the refrigerator for up to 4 days. Reheat in a baking pan set in a 325°F oven coated in a bit of beef broth until warmed through.

Freeze this roast in an airtight container or Ziplock bag (along with the juices) for up to 3 months. Let thaw overnight in the refrigerator before reheating.

A plate with Mississippi pot roast, mashed potatoes, and beef on it.

Serving Suggestions

I like to serve this tasty Mississippi pot roast with creamy mashed potatoes, basmati rice, egg noodles, or on sandwich buns (I love Hawaiian rolls). Some roasted veggies, dill pickle pasta salad, or a light cucumber salad would make great sides!

Use leftovers to make my favorite slow cooker Italian beef sandwiches!

5-Star Review

“I’ve been making beef roast for more than sixty years. This is the BEST of the best. My new go-to for my many “resort-type” guests. Just subscribed to your emails, and I’m making your crock pot chicken with marmalade and pineapple today. Thanks!” – Kristine Zuleger

Recipe Card

Crockpot Mississippi Pot Roast Recipe

4.57 from 96 votes
Prep: 10 minutes
Cook: 6 hours 30 minutes
Total: 6 hours 40 minutes
Servings: 6
Author: Becky Hardin
A slow cooker filled with Mississippi pot roast.
This crockpot Mississippi pot roast is juicy, tender, and just the right amount of zesty. I love it on tacos, nachos, sliders, and more!
Step-by-step photos can be seen below the recipe card.
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Equipment

  • Crockpot

Ingredients 

  • 3 pound boneless chuck roast top or bottom round roast
  • teaspoons kosher salt
  • 2 teaspoons freshly ground black pepper
  • ¼ cup all-purpose flour
  • 3 tablespoons canola oil
  • 4 tablespoons unsalted butter (½ stick)
  • 12 pepperoncini
  • 2 tablespoons mayonnaise
  • 2 teaspoons apple cider vinegar
  • ½ teaspoon dried dill
  • ¼ teaspoon ground sweet paprika
  • 1 teaspoon buttermilk optional
  • Chopped fresh parsley optional, for garnish

Instructions 

  • Set the roast on a small baking tray and rub it with salt and pepper. Sprinkle the flour over the roast and massage it into the meat.
    3 pound boneless chuck roast, 2½ teaspoons kosher salt, 2 teaspoons freshly ground black pepper, ¼ cup all-purpose flour
    a heart shaped piece of meat on a white plate.
  • In a large skillet, heat the oil over medium high heat until it shimmers. Place the roast in the pan and sear it 4-5 minutes until it browns and a crust forms. Turn the roast over and sear on the other side.
    3 tablespoons canola oil
    a steak in a frying pan on a white background.
  • Spray a crockpot with nonstick spray and place the meat in the bowl. Add the butter and pepperoncini. Cover with the lid and set the machine to LOW.
    4 tablespoons unsalted butter, 12 pepperoncini
    a crock pot filled with meat and vegetables.
  • While the roast heats, combine mayonnaise, vinegar, dill, and paprika in a small bowl to make a ranch dressing. Whisk quickly until emulsified. Add the buttermilk and whisk again. Pour the ranch dressing over the roast, cover, and continue cooking for 4 hours.
    2 tablespoons mayonnaise, 2 teaspoons apple cider vinegar, ½ teaspoon dried dill, ¼ teaspoon ground sweet paprika, 1 teaspoon buttermilk
    a blue bowl of dressing on a white surface.
  • After 4 hours, test to see if the meat is tender enough to shred easily using two forks. If the meat isn’t ready, cook up to 4 more hours, or until the roast is tender, depending on the size of the roast.
    a slow cooker filled with meat and vegetables.
  • To serve, shred the meat and mix the gravy together with the roast. If desired, purée the roast “gravy” with a hand or stick blender, then mix it with the shredded roast. Garnish with chopped parsley and serve with egg noodles, potatoes or on sandwich rolls. Use your imagination.
    Chopped fresh parsley
    shredded beef in a baking pan with a fork.

Video

Becky’s Tips

Recipe adapted from The New York Times.
Storage: Store Mississippi pot roast in an airtight container in the refrigerator for up to 4 days or in the freezer for up to 3 months.
Serving: 0.5poundCalories: 596kcalCarbohydrates: 6gProtein: 45gFat: 44gSaturated Fat: 17gPolyunsaturated Fat: 7gMonounsaturated Fat: 20gTrans Fat: 2gCholesterol: 179mgSodium: 1187mgPotassium: 829mgFiber: 1gSugar: 0.5gVitamin A: 385IUVitamin C: 17mgCalcium: 51mgIron: 5mg

Nutrition information is automatically calculated, so should only be used as an approximation.

Did you make this? Leave a comment!

How to Make Mississippi Pot Roast Step by Step

Season the Meat: Set a 3-pound boneless chuck roast on a small baking tray and rub it with 2½ teaspoons of kosher salt and 2 teaspoons of ground black pepper. Sprinkle ¼ cup of flour over the roast and massage it into the meat.

a heart shaped piece of meat on a white plate.

Sear the Meat: In a large skillet, heat 3 tablespoons of canola oil over medium-high heat until it shimmers. Place the roast in the pan and sear it for 4-5 minutes, until it browns and a crust forms. Turn the roast over and sear on the other side.

a steak in a frying pan on a white background.

Cook the Meat: Spray a crockpot with nonstick spray and place the meat in the bowl. Add 4 tablespoons of unsalted butter and 12 pepperoncini. Cover with the lid and set the machine to LOW.

a crock pot filled with meat and vegetables.

Make the Dressing: While the roast heats, combine 2 tablespoons of mayonnaise, 2 teaspoons of apple cider vinegar, ½ teaspoon of dried dill, and ¼ teaspoon of ground sweet paprika in a small bowl to make a ranch dressing. Whisk quickly until emulsified. Add 1 teaspoon of buttermilk and whisk again. Pour the ranch dressing over the roast, cover, and continue cooking for 4 hours.

a blue bowl of dressing on a white surface.

Check For Doneness: After 4 hours, test to see if the meat is tender enough to shred easily using two forks (internal temp should be 195-200°F in the thickest part). If the meat isn’t ready, cook up to 4 more hours, or until the roast is tender, depending on the size of the roast.

a slow cooker filled with meat and vegetables.

Shred and Serve: To serve, shred the meat and mix the gravy together with the roast. If desired, purée the roast “gravy” with a hand or stick blender, then mix it with the shredded roast. Garnish with chopped parsley and serve with egg noodles, potatoes, or on sandwich rolls. Use your imagination.

shredded beef in a baking pan with a fork.

More Crockpot Recipes to Try!

Meet Becky Hardin

Becky Hardin is a wife and mother living in Saint Louis Missouri. She founded The Cookie Rookie in 2012 as a creative way to share recipes. Now, she is a trusted resource for easy cooking around the world, being featured in Taste of Home, The Kitchn, ABC’s Home and Family, and more. Here at The Cookie Rookie she is the editor in chief of all recipes and continues to enjoy sharing her passion for cooking for busy families. She has since founded two additional food blogs, Easy Chicken Recipes and Easy Dessert Recipes.

4.57 from 96 votes (86 ratings without comment)
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45 Comments
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Alaina
Alaina
July 25, 2023 7:56 pm

We usually have our dinners planned out for the week but today we weren’t sure what to make. Came across this recipe this morning and ran out to get ingredients for the slow cooker. It was so easy and delicious! I wish we had more leftovers!5 stars

Amanda
Amanda
March 4, 2023 9:30 am

What is the gravy ?

Samantha Marceau
March 6, 2023 9:53 am
Reply to  Amanda

Hi Amanda, the gravy refers to the juices that are left in the crockpot after cooking!

Katie
Katie
October 17, 2022 6:59 pm

You do not need the butter in this recipe. I repeat: YOU DO NOT NEED THE BUTTER IN THIS RECIPE. Seriously. Don’t put the butter in. Tasty otherwise.4 stars

Samantha Marceau
October 18, 2022 9:05 am
Reply to  Katie

Thanks for sharing, Katie!

Katie
Katie
July 26, 2022 6:35 am

Do you happen to know the serving size for the nutrition facts? Thank you! Making this tonight!

Samantha Marceau
July 26, 2022 9:26 am
Reply to  Katie

The nutrition facts are based on just about ½-pound servings.

Nina Moyers
Nina Moyers
January 12, 2022 10:27 am

This is my favorite roast! Have you ever made it with potatoes and carrots in the crockpot?5 stars

Becky Hardin
Becky Hardin
January 12, 2022 3:32 pm
Reply to  Nina Moyers

Definitely add those additions!!

Michelle Cohen
Michelle Cohen
May 26, 2021 8:15 pm

Another Cookie Rookie Success! The only change I would make is to get a bigger roast! I served it on Hawaiian rolls.5 stars

Becky Hardin
Becky Hardin
June 2, 2021 2:21 pm
Reply to  Michelle Cohen

Thanks for stopping by and sharing, Michelle!

Kristine Zuleger
Kristine Zuleger
May 9, 2021 6:59 am

I’ve been making beef roast for more than sixty years. This is the BEST of the best. My new go-to for my many “resort-type” guests. Just subscribed to your emeals, and I’m making your crock pot chicken with marmalade and pineapple today. Thanks!5 stars

Becky Hardin
Becky Hardin
May 13, 2021 3:37 pm

Thanks for stopping by and sharing, Kristine!

Heidi Menocal
Heidi Menocal
April 28, 2021 1:58 pm

This is Sam Sifton’s recipe from the NYTimes. He should get the credit.

Jocelyn
Jocelyn
March 8, 2021 9:23 am

Do you put the juice from the pepperochini jar in the crock pot?

Becky Hardin
Becky Hardin
March 10, 2021 3:35 pm
Reply to  Jocelyn

I personally haven’t done it, but definitely give it a shot!

Mark
Mark
July 14, 2020 1:02 pm

In a pinch I used 1/2 of mild Chicago style giardiniera. Omit the salt then. Never went back.5 stars

Becky Hardin
Becky Hardin
July 15, 2020 1:32 pm
Reply to  Mark

I’ll have to try that!!